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Alternative Animal And Non-animal Models For Drug Discovery And Development: Bonus Or Burden?
(Springer/Plenum PublishersNew York, 2017)
Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models
(2017-10-01)
Aim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis ...
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
(2009-10-01)
Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can ...
Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases
(2021-09-16)
Animal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease treatment based on alternative models in a fast, safe, and ...
Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model
(2016-09-01)
Paracoccidioides brasiliensis and P. lutzii belong to a group of thermodimorphic fungi and cause paracoccidioidomycosis (PCM), which is a human systemic mycosis endemic in South and Central America. Patients with this ...
Zebrafish as an alternative animal model in human and animal vaccination research
(Springer, 2020-05-07)
Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most widely used ...
Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection
(Bentham Science Publ Ltd, 2018)
The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of ...
Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease
(Wiley-Blackwell, 2018-06-01)
The mitochondrial respiratory chain in vertebrates and arthropods is different from that of most other eukaryotes because they lack alternative enzymes that provide electron transfer pathways additional to the oxidative ...
Semiparametric animal models via penalized splines as alternatives to models with contemporary groups
(American Society of Animal Science, 2005-11-01)
Contemporary groups (CG) are used in genetic evaluation to account for systematic environmental effects of management, nutritional level, or any other differentially expressed group effect; however, because the functional ...
Modelo experimental de úlcera traumática em mucosa jugal de ratos
(2011-05-01)
Purpose: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. Methods: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the ...