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Regulatory network of the allosteric ATP inhibition of E. coli phosphofructokinase-2 studied by hybrid dimers
(Elsevier B.V., 2016)
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) We have proposed an allosteric ATP inhibition mechanism of Pfk-2 determining the structure of different forms of the enzyme together ...
A Novel Dual Allosteric Activation Mechanism of Escherichia coli ADP-glucose Pyrophosphorylase: The role of pyruvate
(Public Library Of Science, 2014-07)
Fructose-1,6-bisphosphate activates ADP-glucose pyrophosphorylase and the synthesis of glycogen in Escherichia coli. Here, we show that although pyruvate is a weak activator by itself, it synergically enhances the ...
The water effect on allosteric regulation of hemoglobin probed in water glucose and water glycine solutions
(Amer Soc Biochemistry Molecular Biology Inc, 1996-03-01)
We have previously proposed a role of hydration in the allosteric control of hemoglobin based on the effect of varying concentrations of polyols and polyethers on the human hemoglobin oxygen affinity and on the solution ...
The water effect on allosteric regulation of hemoglobin probed in water glucose and water glycine solutions
(Amer Soc Biochemistry Molecular Biology Inc, 2014)
The water effect on allosteric regulation of hemoglobin probed in water glucose and water glycine solutions
(Amer Soc Biochemistry Molecular Biology Inc, 2014)
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach
(Public Library Science, 2019-01-25)
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of ...
ADPglucose pyrophosphorylase's N-terminus: Structural role in allosteric regulation
(Academic Press Inc Elsevier Science, 2006-04)
We studied the functional role of the Escherichia coli ADPglucose pyrophosphorylase's N-terminus in allosteric regulation, and the particular effects caused by its length. Small truncated mutants were designed, and those ...
A Chimeric UDP-Glucose Pyrophosphorylase Produced by Protein Engineering Exhibits Sensitivity to Allosteric Regulators
(Molecular Diversity Preservation International, 2013-05)
In bacteria, glycogen or oligosaccharide accumulation involves glucose-1-phosphate partitioning into either ADP-glucose (ADP-Glc) or UDP-Glc. Their respective synthesis is catalyzed by allosterically regulated ADP-Glc ...
Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling
(Springer, 2019)
Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector ...
Understanding the allosteric trigger for the fructose-1,6-bisphosphate regulation of the ADP-glucose pyrophosphorylase from Escherichia coli
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011-10)
ADP-glucose pyrophosphorylase is the enzyme responsible for the regulation of glycogen synthesis in bacteria. The enzyme N-terminal domain has a Rossmann-like fold with three neighbor loops facing the substrate ATP. In the ...