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QSAR prediction of inhibition of aldose reductase for flavonoids
(Pergamon-Elsevier Science Ltd, 2008-06)
We performed a predictive analysis based on quantitative structure–activity relationships (QSAR) of an important property of flavonoids, which is the inhibition (IC50) of aldose reductase (AR). The importance of AR inhibition ...
Self-organizing maps and VolSurf approach to predict aldose reductase inhibition by flavonoid compounds
(Sociedade Brasileira de Farmacognosia, 2011)
Aldose Reductase (AR) is the polyol pathway key enzyme which converts glucose to sorbitol. High glucose availability in insulin resistant tissues in diabetes leads into an accumulation of sorbitol, which has been associated ...
Regulation of aldose reductase activity by tubulin and phenolic acid derivates
(Elsevier Science Inc, 2018-09-15)
In this work we demonstrate that aldose reductase (AR) interacts directly with tubulin and, was subjected to microtubule formation conditions, enzymatic AR activity increased more than sixfold. Since AR interacts mainly ...
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
Structural and kinetic characterization of a maize aldose reductase
(Elsevier France-editions Scientifiques Medicales ElsevierParisFrança, 2009)
2-tiopirimidinonas : síntese, funcionalização e avaliação do potencial de inibição para a enzima aldose redutase
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Quimica, 2020)
Inhibition of recombinant aldose-6-phosphate reductase from peach leaves by hexose-phosphates, inorganic phosphate and oxidants
(Oxford University Press, 2017-01)
Glucitol, also known as sorbitol, is a major photosynthetic product in plants from the Rosaceae family. This sugar alcohol is synthesized from glucose-6-phosphate by the combined activities of aldose-6-phosphate reductase ...
Early potential impairment of renal sensory nerves in streptozotocin-induced diabetic rats: role of neurokinin receptors
(Oxford Univ PressOxfordInglaterra, 2011)
Sobre el almacenamiento del carbono en células autótrofas y heterótrofas. Caracterización cinética y estructural de enzimas del metabolismo de azúcares y azúcares-alcoholes
(2016-03-10)
Las plantas son organismos complejos que deben integrar respuestas internas y estímulos externos para coordinar su desarrollo, regulando finamente la síntesis y el uso del carbono. En la mayoría, el carbono fijado ...