Buscar
Mostrando ítems 1-10 de 1525
Modulation of the Akt pathway reveals a novel link with PERK/eIF2alpha, which is relevant during hypoxia
(Public Library Science, 2013-07-29)
The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied ...
AKT
(Springer, 2018)
AKT is a serine/threonine kinase member of the AGC family of protein kinases. The three isoforms of AKT (AKT1/2/3) play a central role in growth, proliferation, glucose uptake, metabolism, protein translation and cell ...
PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage
(Informa Healthcare, 2019-10)
Based on the inflammatory nature and hormone-dependency of endometriosis, PI3K/AKT signaling appears to influence its progression. Could the endometriosis stages be linked to differential changes in PI3K/AKT pathway ...
Study of PI3K/AKT/mTOR pathway in breast cancer progression
(Instituto de Histología y Embriología, 2018)
Deregulation in the PI3K/AKT/mTOR pathway is associated with breast cancer development. Using experimental models of breast carcinogenesis induced in mice, xenografts of tumor cell lines, and tumors from patients we found ...
Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3-L1 Adipocytes
(2019-02-01)
Adipose tissue (AT), an endocrine organ that modulates several physiological functions by synthesizing and releasing adipokines such as adiponectin, is a metabolic target of triiodothyronine (T3). T3 and adiponectin play ...
AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival
(Nature Publishing Group, 2016-10)
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, ...
Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
(Springer Wien, 2014-12)
In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, ...
Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
(Springer, 2010-02)
Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression ...
Akt/AS160 Signaling pathway inhibition impairs infection by decreasing rab14-controlled sphingolipids delivery to chlamydial inclusions
(Frontiers Media S.A., 2019-04)
Chlamydia trachomatis, an obligate intracellular bacterium, intercepts different trafficking pathways of the host cell to acquire essential lipids for its survival and replication, particularly from the Golgi apparatus via ...