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Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors
(ENDOCRINE SOC, 2008)
Background: Adrenocortical tumors are heterogeneous neoplasms with incompletely understood pathogenesis. IGF-II overexpression has been consistently demonstrated in adult adrenocortical carcinomas. Objectives: The objective ...
Steroidogenic Factor 1 Overexpression and Gene Amplification Are More Frequent in Adrenocortical Tumors from Children than from Adults
(ENDOCRINE SOC, 2010)
Background: Steroidogenic factor 1 (SF-1) is a key determinant of endocrine development and function of adrenal cortex. SF-1 overexpression and gene amplification were previously demonstrated in a small group of pediatric ...
Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors
(HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)
OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional ...
Clinical characteristics of small functioning adrenocortical tumors in children
(Wiley-Blackwell, 1997-03-01)
Twenty of 67 children registered on the International Registry of Childhood Adrenocortical Tumors between May 1988 and December 1994 had small adrenocortical tumors (defined for this study as measuring less than or equal ...
Igf2 And Igf1r In Pediatric Adrenocortical Tumors: Roles In Metastasis And Steroidogenesis
(BIOSCIENTIFICA LTDBRISTOL, 2016)
A study of adrenocortical tumors in children and adolescents by a comparative genomic hybridization technique
(ELSEVIER SCIENCE INC, 2011)
Adrenocortical tumors (ACT) are rare neoplasms of the adrenal glands accounting for 0.2% of all pediatric cancers. However, the incidence of ACT in South Brazilian children is 10 to 15 times greater than the worldwide ...
Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor
(Sociedade Brasileira de Endocrinologia e Metabologia, 2011)
The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival ...
Expression profiles of the glucose-dependent insulinotropic peptide receptor and LHCGR in sporadic adrenocortical tumors
(BIOSCIENTIFICA LTD, 2009)
Glucose-dependent insulinotropic peptide receptor (GIPR) and LHCGR are G-protein-coupled receptors with a wide tissue expression pattern. Aberrant expression of these receptors has rarely been demonstrated in adult sporadic ...