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Adipose tissue macrophages as a therapeutic target in obesity-associated diseases
(Blackwell Publishing Ltd, 2021-01-10)
Obesity is an increasing problem in developed and developing countries. Individuals with obesity have a higher risk of several diseases, such as cardiovascular disease, increased risk of insulin resistance, type 2 diabetes, ...
Pafr In Adipose Tissue Macrophages Is Associated With Anti-inflammatory Phenotype And Metabolic Homoeostasis
(PORTLAND PRESS LTDLONDON, 2016)
Comment on: Kim et al. Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders. Diabetes 2011;60:3159-3168
(American Diabetes Association, 2012-07)
In the December 2011 issue of Diabetes, Kim et al. [1] reported that 4-1BB (CD137/TNFRSF9) deficiency protected against high fat diet (HFD)-induced obesity, glucose intolerance and fatty liver disease. They found that 4-1BB ...
Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome
(2018)
Context Polycystic ovary syndrome (PCOS) is an androgen excess disorder associated with obesity and adipose tissue disturbances. Our aim was to evaluate gene expression of adipocytokines and adipocyte characteristics in ...
Macrophage polarization: implications on metabolic diseases and the role of exercise
(Consel Brasil Oftalmologia, 2016)
Macrophages are cells of the innate immune response that trigger inflammation resolution. The phenotype of "classically activated macrophages" (M1) has anti-tumoricidal and anti-bactericidal activities. On the other hand, ...
M1 macrophage subtypes activation and adipocyte dysfunction worsen during prolonged consumption of a fructose-rich diet
(Elsevier Science Inc, 2018-11)
Fructose-rich diet (FRD) has been associated with obesity development, which is characterized by adipocytes hypertrophy and chronic low-grade inflammation. Interaction of adipocytes and immune cells plays a key role in ...
Effects of dietary supplementation with EPA and/or -lipoic acid on adipose tissue transcriptomic profile of healthy overweight/obese women following a hypocaloric diet
(WILEY, 2017)
In obesity, the increment of adiposity levels disrupts the whole body homeostasis, promoting an over production of oxidants and inflammatory mediators. The current study aimed to characterize the transcriptomic changes ...