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Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas
(Springer, 2016-11)
1-(Acyl/aroyl)-3-(substituted)thioureas are privileged architectures that have received remarkable attention of researchers in view of their variable topological aspects, binding modes and broad spectrum promising ...
Current developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3- (substituted)thioureas: advances Continue…
(Taylor & Francis Ltd, 2019)
1-(acyl/aroyl)-3-(substituted)thioureas are exciting structures in the fields of organic synthesis, material sciences, and biomedical research. Of particular significance is the fact that acyl thiourea derivatives have ...
On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas
(ElsevierPhiladelphia, 2014-05)
The rational design of anticancer drugs is one of the most promising strategies for increasing their cytotoxicity and for minimizing their toxicity. Manipulation of the structure of ligands or of complexes represents a ...
Conformational and crystal structure of acyl thiourea compounds: The case of the simple (2,2-dimethyl-propionyl) thiourea derivative
(Elsevier Science, 2020-09-05)
A novel and simple compound from the family of 1-acyl thioureas, namely (2,2-dimethyl-propionyl) thiourea (also named as N-carbamothioyl pivalamide), has been prepared. It has been fully characterized by microelemental ...
A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
(Taylor & Francis Ltd, 2014-04)
This review provides an overview of the chemistry, structure and potential applications of 1- (acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. ...
Acyl thiourea derivatives: a study of crystallographic, bonding, biological and spectral properties
(Elsevier Science, 2019-01)
The study of two new acylthiourea derivatives (Ar-CO-NH-CS-NH-R) are focused on the bonding interactions supported by X-ray, NMR, UV-Vis, Raman and IR spectroscopy, and NBO, AIM and Hirshfeld surface analysis. The RAHB ...
Understanding the conformational changes and molecular structure of furoyl thioureas upon substitution
(Pergamon-Elsevier Science Ltd, 2017-04)
1-Acyl thioureas [R1C(O)NHC(S)NR2R3] are shown to display conformational flexibility depending on the degree of substitution at the nitrogen atom. The conformational landscape and structural features for two closely related ...