Objective: To evaluate the efficacy of lithium in the treatment of acute mania. Method: Systematic overview of the literature and meta-analysis of randomised controlled trials. Estimation of (i) the differences in the ...

Background: The potential value of lithium treatment in particular aspects of unipolar major depressive disorder remains uncertain. Methods: With reports of controlled trials identified by systematic searching of Medline, ...

For adults with acute mania, the effects of lithium compared with different mood stabilizers were mixed, and although differences were noted, few reached statistical significance. The comparative adverse effect pattern ...

Several studies have suggested an important role for brain-derived neurotrophic factor (BDNF) in the pathophysiology and therapeutics of bipolar disorder (BPD). The mechanisms underlying the therapeutic effects of lithium ...

Introduction: Exposure of the human body to high altitude causes a number of physiological changes. In previous studies, we observed that these changes may alter the pharmacokinetics of drugs. The number of erythrocytes/mm(3) ...

Objectives To review data from randomized controlled trials (RCTs) assessing the comparative efficacy of carbamazepine and lithium in treatment of acute manic and maintenance phase of bipolar disorder (BD).Design RCTs were ...

Abstract Background: Successful treatment of major depressive disorder (MDD) can be challenging, and failures ("treatment-resistant depression" [TRD]) are frequent. Steps to address TRD include increasing antidepressant ...