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Alzheimer's disease: Related targets, synthesis of available drugs, bioac-tive compounds under development and promising results obtained from multi-target approaches
(2021-01-01)
We describe herein the therapeutic targets involved in Alzheimer’s disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent ...
EFFECT OF PHOTOSYNTHETIC INHIBITOR HERBICIDES ON NITRATE REDUCTASE ACTIVITY OF NON-TARGET SPECIESEFFECT OF PHOTOSYNTHETIC INHIBITOR HERBICIDES ON NITRATE REDUCTASE ACTIVITY OF NON-TARGET SPECIES
(University of Puerto Rico Mayagüez Campus Agricultural Experiment Station, 1979)
HCN Channels: New therapeutic targets for pain treatment
(MDPI AG, 2018)
Target fishing de análogos beta-carbonílas com atividade anti-leishmanicida
(Universidade Federal do Rio Grande do NorteBrasilUFRNFarmácia, 2020-12-04)
Leishmaniasis is still one of the most neglected diseases in the world, affecting underdeveloped and developing countries, due to the poor sanitary and socioeconomic conditions; 350 million people are considered at risk ...
Nanosystem functionalization strategies for prostate cancer treatment: a review
(2021-01-01)
Prostate cancer (PC) has a high morbidity and mortality rate worldwide, and the current clinical guidelines can vary depending on the stage of the disease. Drug delivery nanosystems (DDNs) can improve biopharmaceutical ...
Prediction of drug targets in human pathogens
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The rapid emergence of resistant bacteria makes today's antibiotics more and more ineffective, consequently increasing the need for new pharmacological targets and novel classes of antibacterial drugs. The identification ...
Highlights in targeted nanoparticles as a delivery strategy for glioma treatment
(2021-07-15)
Glioma is the most common type of Central Nervous System (CNS) neoplasia and it arises from glial cells. As glial cells are formed by different types of cells, glioma can be classified according to the cells that originate ...
Nanostructure empowers active tumor targeting in ligand-based molecular delivery
(Wiley VCH Verlag, 2019-10-16)
Cell‐selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor‐mediated selective ...
Active X-ray testing of complex objects
(BRITISH INST NON-DESTRUCTIVE TESTING, 2012)
X-ray testing of complex objects - such as luggage screening at airports - is usually performed manually. This is not always effective, since it depends strongly on the pose of the objects of interest (target objects) and ...