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Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor
(Nature Research, 2011)
Abstract: Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis, and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report the occurrence of a cholesterol ...
Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution
(American Society for Biochemistry and Molecular Biology, 2010-09)
The nicotinic acetylcholine receptor (AChR) is in intimate contact with the lipids in its native membrane. Here we analyze the possibility that it is the intrinsic properties of the AChR that determine its partition into ...
Targeting Brain alpha;7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Adis Int Ltd, 2014-11)
Alzheimer´s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Estudio de la interacción lípido-proteína sobre la función y la organización del receptor de acetilcolina nicotínico en membranas y en sistemas modelos simples
(2014-12-16)
En esta Tesis doctoral se profundizó en el estudio de la interacción lípido-receptor de acetilcolina nicotínico (AChR) en dos aspectos: por un lado, el mecanismo de inhibición de ácidos grasos libres (AGLs), antagonistas ...
Chaperoning a7 neuronal nicotinic acetylcholine receptors
(Elsevier, 2012-03)
The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cysloop family of receptors present in the central nervous system. It participates in various physiological processes ...
Statistical Analysis of High-Resolution Light Microscope Images Reveals Effects of Cytoskeleton-Disrupting Drugs on the Membrane Organization of the Nicotinic Acetylcholine Receptor
(Springer, 2010-06)
Extensive evidence supports the notion that the cytoskeleton participates in the immobilization and mem- brane clustering of the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. Stimulated emission ...