Buscar
Mostrando ítems 1-10 de 40334
ACE gene polymorphism and severe lung injury in patients with COVID-19
COVID-19 has markedly varied clinical presentations, with the majority of patients being
asymptomatic or having mild symptoms. However, severe acute respiratory disease
caused by SARS-CoV-2 is common and associated with ...
Characterization of angiotensin-converting enzymes 1 and 2 in the soleus and plantaris muscles of rats
(Associação Brasileira de Divulgação Científica, 2010)
Angiotensin-converting enzymes 1 (ACE1) and 2 (ACE2) are key enzymes of the renin-angiotensin system, which act antagonistically to regulate the levels of angiotensin II (Ang II) and Ang-(1-7). Considerable data show that ...
ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser(1270)
(PUBLIC LIBRARY SCIENCE, 2011)
Objectives: We tested whether angiotensin converting enzyme (ACE) and phosphorylation of Ser(1270) are involved in shear-stress (SS)-induced downregulation of the enzyme. Methods and Results: Western blotting analysis ...
ACE2, the Receptor that Enables the Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators
(Wiley VCH Verlag, 2020-07)
Angiotensin Converting Enzyme 2 (ACE2) is the human receptor that interacts with the Spike protein of coronaviruses, including the one that produced the 2020 coronavirus pandemic (COVID-19). Thus, ACE2 is a potential target ...
Renin-angiotensin system may trigger kidney damage in NOD mice
(Sage Publications Ltd, 2011-03-01)
Diabetic nephropathy is a complication of diabetes and one of the main causes of end-stage renal disease. A possible causal link between renin-angiotensin aldosterone system (RAAS) and diabetes is widely recognized but the ...
ACE2, Metformin, and COVID-19
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective
therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to
COVID-19 pathogenesis, as the binding ...
Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture
(Lippincott Williams & Wilkins, 1998-12-01)
Objective Previous analysis of the angiotensin I-converting enzyme (ACE) gene in this laboratory showed that primary mesangial cells in culture are able to express ACE mRNA. Moreover, ACE is produced as an ectoenzyme and ...
ACE2 a double-edged sword?
(2020)
Ace gene dosage influences the development of renovascular hypertension
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
P>1. Clinical and experimental evidence highlights the importance of the renin-angiotensin system in renovascular hypertension. Furthermore, genetic factors affecting angiotensin-converting enzyme (ACE) could influence the ...