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A phenolic-rich extract from ugni molinae berries reduces abnormal protein aggregation in a cellular model of huntington's disease
(Public Library Science, 2021)
Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds ...
Targeting autophagy in ALS: A complex mission
(Taylor and Francis Inc., 2011)
Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
(Bentham Science Publishers, 2011-05)
Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one ...
Synaptic control of local translation: the plot thickens with new characters
(Springer, 2013-11)
The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and ...
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(National Academy of Sciences, 2018)
Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...
Targeting autophagy in neurodegenerative diseases
(Elsevier Ltd, 2014)
© 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(National Academy of Sciences, 2018)
© National Academy of Sciences. All rights reserved. Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1WT) is also ...
Seeding of oligomers: new strategies for Alzheimer´s diagnosis and possible implications for the progression of the disease
(Universisdad de Chile, 2010)
Alzheimer's disease (AD) is a complex neurodegenerative condition which has become a
major public health problem because of its increasing prevalence, long duration and high cost
of care. It is estimated than more than ...
Protein misfolding, signaling abnormalities and altered fast axonal transport: Implications for Alzheimer and Prion diseases
(Frontiers Media S.A., 2019-07)
Histopathological studies revealed that progressive neuropathies including Alzheimer, and Prion diseases among others, include accumulations of misfolded proteins intracellularly, extracellularly, or both. Experimental ...
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(2018)
Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...