The etiology of gonadal failure with infertility in men and women may have a genetic, environmental, or autoimmune basis. The major support for an autoimmune basis has come from studies on patients with the autoimmune ...

Experimental studies predict a frequent occurrence of human gonadal autoimmunity. In spontaneous multi-organ models of autoimmune diseases, the testis and ovary are frequent targets. Although progress in clinical research ...

A high prevalence of menstrual cycle and fertility disturbances has long been associated with diabetes mellitus. However, rationalization of the intrinsic mechanisms of these alterations is controversial and even contradictory. ...

ADAMTS proteins (disintegrins and metalloproteinases with thrombospondin motifs) have been associated with various biological processes including follicular development and ovulation. Some members are considered orphan ...