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Atorvastatin increases oxidative stress and inhibits cell migration of oral squamous cell carcinoma in vitro
(2019-03-01)
Objective: This study aimed to evaluate the effect of atorvastatin treatment on reactive oxygen species (ROS) production and tumor angiogenesis in oral squamous cell carcinomas. Material and Methods: An HN13 cell line was ...
A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
(Sociedad Chilena de Química, 2010)
Antinociception induced by atorvastatin in different pain models
(2011)
Atorvastatin is a statin that inhibits the 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. Several landmark clinical trials have demonstrated the beneficial effects of statin therapy for primary and secondary ...
STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
(Sociedad Chilena de Química, 2010)
Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
(Sociedad Chilena de Anatomía, 2011)
A Validated Reversed-Phase HPLC Method for the Determination of Atorvastatin Calcium in Tablets
(Austin Publishing Group, 2014-09)
A Reversed-Phase Liquid Chromatographic (RP-LC) assay method was developed for the quantitative determination of atorvastatin calcium in the presence of its degradation products. The assay involved an isocratic elution of ...
Atorvastatin and hormone therapy effects on APOE mRNA expression in hypercholesterolemic postmenopausal women
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Menopause is associated with changes in lipid levels resulting in increased risk of atherosclerosis and cardiovascular events. Hormone therapy (HT) and atorvastatin have been used to improve lipid profile in postmenopausal ...
The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial
(Nature Research, 2020-06-01)
Atorvastatin (ATV) is a blood cholesterol-lowering drug used to prevent cardiovascular events, the leading cause of death worldwide. As pharmacokinetics, metabolism and response vary among individuals, we wanted to determine ...
Decreased ABCB1 mRNA expression induced by atorvastatin results from enhanced mRNA degradation in HepG2 cells
(ELSEVIER SCIENCE BV, 2009)
The mechanisms underlying atorvastatin supression of ABCB1 gene expression, at transcriptional and post-transcriptional levels of ABCB1 gene in HepG2 (human hepatocellular carcinoma) cells were investigated. Quantitative ...
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone
(Associação Brasileira de Divulgação Científica, 2007-03-01)
Animal studies and premarketing clinical trials have revealed hepatotoxicity of statins, primarily minor elevations in serum alanine aminotransferase levels. The combined chronic use of medicines and eventual ethanol abuse ...