Buscar
Mostrando ítems 1-10 de 657
Relative transcription of autophagy-related genes in Amblyomma sculptum and Rhipicephalus microplus ticks
(Springer Verlag (Germany), 2018)
Análisis del nivel de ARNm de ATG4, ATG17 y ATG18a en células envejecidas de Schizosaccharomyces pombe. Generación de la construcción interruptora de los genes ATG4 y ATG17.
(Benemérita Universidad Autónoma de Puebla, 2017-12)
"El envejecimiento es referido como el deterioro progresivo de las funciones fisiológicas a nivel tisular, celular y molecular, donde existe una gran acumulación de daño debido a una pérdida en la homeostasis, lo que lleva ...
Identification and pharmacological induction of autophagy in the larval stages of Echinococcus granulosus: an active catabolic process in calcareous corpuscles
(Elsevier, 2014-06)
Autophagy is a fundamental catabolic pathway conserved from yeast to mammals, but which remains unknown in parasite cestodes. In this work, the pharmacological induction of autophagy was cellularly and molecularly analysed ...
A retrospective comparison of cyclophosphamide plus antithymocyte globulin with cyclophosphamide plus busulfan as the conditioning regimen for severe aplastic anemia
(Associação Brasileira de Divulgação Científica, 2009-03-01)
Allogeneic hematopoietic stem cell transplantation (AHSCT) is the treatment of choice for young patients with severe aplastic anemia (SAA). The association of antithymocyte globulin (ATG) and cyclophosphamide (CY) is the ...
ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure
Purpose: Primary ovarian insufficiency (POI) is a frequent disorder that affects ~1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels ...
Autophagy-related 16-like 1gene polymorphism, risk factors for cardiovascular disease and associated carotid intima-media thickness in postmenopausal women
(2018-11-01)
Background: Early identification of asymptomatic postmenopausal women (PW), who are more predisposed to developing cardiovascular disease (CVD), is an important preventive strategy. Autophagy-related 16-like 1 (ATG16L1) ...
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism
(Taylor and Francis, 2016)
Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 ...
Brazilian experience with two conditioning regimens in patients with multiple sclerosis: BEAM/horse ATG and CY/rabbit ATG
(NATURE PUBLISHING GROUP, 2010)
Studies have shown that autologous hematopoietic SCT (HSCT) can be used as an intensive immunosuppressive therapy to treat refractory patients and to prevent the progression of multiple sclerosis (MS). This is a prospective ...
Avaliação da segurança e eficácia do tratamento de anemia aplásica com alentuzumabe: estudo retrospectivo e multicêntrico internacional
(Universidade Federal de São Paulo, 2023-05-24)
Introdução: A anemia aplásica (AA) é uma doença rara e potencialmente fatal. A hematopoese é profundamente reduzida nos casos graves da doença (anemia aplásica grave - AAG), provavelmente devido à destruição imune de ...