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Fast Biofilm Penetration and Anti-PAO1 Activity of Nebulized Azithromycin in Nanoarchaeosomes
(American Chemical Society, 2020-01)
Azithromycin (AZ) is a broad-spectrum antibiotic with anti-inflammatory and antiquorum sensing activity against biofilm forming bacteria such as Pseudomonas aeruginosa. AZ administered by oral or parenteral routes, however, ...
Make it simple: (SR-A1+TLR7) Macrophage targeted NANOarchaeosomes
(Frontiers Media S.A., 2018-11)
Hyperhalophilic archaebacteria exclusively produce sn2,3 diphytanylglycerol diether archaeolipids, unique structures absent in bacteria and eukaryotes. Nanovesicles made of archaeolipids known as nanoarchaeosomes (nanoARC), ...
Macrophage apoptosis using alendronate in targeted nanoarchaeosomes
(Elsevier Science, 2021-03)
Nanoarchaeosomes are non-hydrolysable nanovesicles made of archaeolipids, naturally functionalised with ligand for scavenger receptor class 1. We hypothesized that nitrogenate bisphosphonate alendronate (ALN) loaded ...
Reparation of an inflamed air-liquid interface cultured a549 cells with nebulized nanocurcumin
(Multidisciplinary Digital Publishing Institute, 2021-08)
The anti-inflammatory, antifibrotic and antimicrobial activities of curcumin (CUR) are missed because of its low solubility in aqueous media, low bioavailability, and structural lability upon oral intake. Soft nanoparticles ...
Structural features of ultradeformable archaeosomes for topical delivery of ovalbumin
(Elsevier Science, 2014-05)
The ultradeformable archaeosomes (UDA, made of total polar archaeolipids (TPA) extracted from the extreme halophile archaea Halorubrum tebenquichense:soybean phosphatidylcholine (SPC):sodium cholate (NaChol), 3:3:1 w:w), ...