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Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents
(2020-06-01)
Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic screening of extract libraries. The present study evaluated ...
Novel sulfonamide compounds for inhibition of metastatic tumor growth (WO2012021963)
(Informa Healthcare, 2013)
A series of novel ureido-sulfonamides was prepared by reaction of aminobenzenesulfonamide with alkyl/aryl isocyanate. These compounds are claimed for use as therapeutic agents of metastatic tumors, which are poorly responsive ...
Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells–Letter
(American Association for Cancer Research, 2016-08)
Blood-borne spread is responsible for the vast majority of cancer-related deaths, and it is recognized that clusters of circulating tumor cells (CTC) are much more likely to cause metastasis than single CTCs. In the November ...
A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway
(Frontiers Media, 2020-02)
The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the ...
The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
(Pergamon-elsevier Science Ltd, 2015-09)
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses ...
A penicillin derivative exerts an anti-metastatic activity in melanoma cells through the downregulation of Integrin αvβ3 and wnt/β-catenin pathway
(Frontiers Media, 2020)
Abstact: The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated ...
Antimetastatic effects of VOflavonoid complexes on A549 cell line
(Elsevier Gmbh, 2021-03)
Background: Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and more than 90 % of mortality is due to metastasis-related deaths. Flavonoids are considered nutraceuticals due to the variety of ...
Singular interaction between an antimetastatic agent and the lipid bilayer: The ohmline case
(American Chemical Society, 2017-10)
SK3 channels are abnormaly expressed in metastatic cells, and Ohmline (OHM), an ether lipid, has been shown to reduce the activity of SK3 channels and the migration capacity of cancer cells. OHM incorporation into the ...
Analyzing Ru(III)-dmso and Ru(III)-dms motifs in compounds used in the synthesis of the antimetastatic agents
(ELSEVIER SCIENCE BV, 2008)
The chemistry of Ru(III) complexes containing dmso as a ligand has become an interesting area in the cancer treatment field. Because of this, structural knowledge and chemistry of the moiety Ru(III)-dmso have become important ...