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Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds
(2016-04-01)
In the last decades, the increased number of immunocompromised patients has led to the emergence of many forms of fungal infections. Furthermore, there are a restricted arsenal of antifungals available and an increase in ...
Antifungal activity of traditional medicinal plants from Argentina: effect of their combination with antifungal drugs
(Bentham Science Publishers, 2019-02)
The incidence of fungal infections has experienced a marked increase in the last two decades being limited to a few drugs with serious drawbacks. Combination therapy has emerged as an approach to improve the efficacy of ...
Alternative treatment of fungal infections: Synergy with non-antifungal agents
(Wiley Blackwell Publishing, Inc, 2021-03)
Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies ...
Antifungal stewardship in low- and middle-income countries
(Springer Nature, 2019-07)
Anfifugal stewardship refers to coordinated interventions designed to improve and measere the appropiate use of antifungals by promouting the selection of the optimal antifungal drug regimen,dose,duration of therapy,and ...
Antifungal therapy: New advances in the understanding and treatment of mycosis
(2017-01-23)
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is ...
Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans
(Medicina Oral, Patología Oral y Cirugía Bucal., 2011)
Objective: The aim of this work was to assess the antifungal and post-antifungal effects of chlorhexidine, fluconazole,
chitosan and its combinations on virulence factors of Candida albicans.
Study Design: Ten isolated ...
Role of antifungal combinations in difficult to treat candida infections
(Multidisciplinary Digital Publishing Institute, 2021-09)
Candida infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. C. albicans is the most prevalent species isolated, however, a significant shift towards other Candida ...
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.
(2016-12-01)
We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate ...
Effect of cold atmospheric plasma jet associated to polyene antifungals on Candida albicans biofilms
(MDPI, 2021-09-25)
: The increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold ...