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Antibody-induced crosslinking and cholesterol-sensitive, anomalous diffusion of nicotinic acetylcholine receptors
(Wiley Blackwell Publishing, Inc, 2020-03)
Synaptic strength depends on the number of cell-surface neurotransmitter receptors in dynamic equilibrium with intracellular pools. Dysregulation of this homeostatic balance occurs, for example in myasthenia gravis, an ...
Antibody-induced crosslinking and cholesterol-sensitive, anomalous diffusion of nicotinic acetylcholine receptors
(Wiley, 2020)
Abstract: Synaptic strength depends on the number of cell-surface neurotransmitter receptors in dynamic equilibrium with intracellular pools. Dysregulation of this homeostatic balance occurs, for example in myasthenia ...
Transient Cholesterol Effects on Nicotinic Acetylcholine Receptor Cell-Surface Mobility
(Public Library of Science, 2014-06)
To what extent do cholesterol-rich lipid platforms modulate the supramolecular organization of the nicotinic acetylcholine receptor (AChR)? To address this question, the dynamics of AChR particles at high density and its ...
Transient cholesterol effects on nicotinic acetylcholine receptor cell-surface mobility
(Public Library of Science, 2014)
Abstract: To what extent do cholesterol-rich lipid platforms modulate the supramolecular organization of the nicotinic acetylcholine receptor (AChR)? To address this question, the dynamics of AChR particles at high density ...
Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis
(Elsevier, 2021)
Abstract: Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction
of voluntary muscles. The classical form of this autoimmune disease is characterized by the
presence of antibodies against ...
Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis
(Shenyang Editorial Dept Neural Regeneration Res, 2021-02)
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most ...
Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
(Springer, 2021-10)
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles ...
Impairment of agonist-induced M2 muscarinic receptor activation by autoantibodies from chagasic patients with cardiovascular dysautonomia
(Academic Press Inc Elsevier Science, 2020-03)
Previous studies showed that circulating autoantibodies against M2 muscarinic receptors (anti-M2R Ab) are associated with decreased cardiac parasympathetic modulation in patients with chronic Chagas disease (CD). Here we ...
Clonagem, expressão em células humanas HEK293 e caracterização de uma proteína recombinante multimérica correspondente ao domínio de ligação ao receptor da proteína Spike do SARS-CoV-2
(Universidade Federal de São Paulo, 2023)
A doença COVID-19 responsável pela pandemia causada pelo vírus SARS-CoV-2 deixou mais de 6,6 milhões de mortes no mundo. O vírus SARS-CoV-2 é um betacoronavírus que pertence a família coronaviridae, possui aproximadamente ...