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Antibody specific B-cell epitope predictions: Leveraging information from antibody-antigen protein complexes
(Frontiers Media S.A., 2019-02)
B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using receptors secreted or expressed on their surface (antibodies). This is achieved via molecular interactions between the paratope ...
Benchmark datasets of immune receptor-epitope structural complexes
(BioMed Central, 2019-10)
Background: The development of accurate epitope prediction tools is important in facilitating disease diagnostics, treatment and vaccine development. The advent of new approaches making use of antibody and TCR sequence ...
The Immune Epitope Database and Analysis Resource Program 2003–2018: reflections and outlook
(Springer, 2019-11)
The Immune Epitope Database and Analysis Resource (IEDB) contains information related to antibodies and T cells across an expansive scope of research fields (infectious diseases, allergy, autoimmunity, and transplantation). ...
BepiPred-2.0: Improving sequence-based B-cell epitope prediction using conformational epitopes
(Oxford University Press, 2017-07)
Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner. ...
Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies
(Springer, 2020)
Pandemics caused by influenza A virus (IAV) are responsible for the deaths of millions of humans around the world. One of these pandemics occurred in Mexico in 2009. Despite the impact of IAV on human health, there is no ...