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Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome
(Scientific Research, 2017-07)
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS). Main methods: We detected the levels of M3mAChR peptide ...
Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome
(OMICS International, 2014-12)
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors ...
Anti-M3 muscarinic acetylcholine receptor antibodies in systemic lupus erythematosus
(Scientific Research, 2015-01)
Background: Evidences have shown that anti-M3 muscarinic acetylcholine receptor IgG (anti-M3 mAChR IgG) are clinically useful autoantibody that exert a cholinergic pharmacologic effect binding and interacting with M3 mAChR ...
Action of anti-M3 muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland
(Wiley, 2015-11)
BACKGROUND: We demonstrate that serum immunoglobulin G (IgG) directed against glandular M3 muscarinic acetylcholine receptors (M₃mAChR) and pilocarpine triggers the increment of superoxide dismutase (SOD) and catalase (CAT) ...
Anti-M3 muscarinic cholinergic autoantibodies from patients with primary Sjögren's syndrome trigger production of matrix metalloproteinase-3 (MMP-3) and prostaglandin E2 (PGE2) from the submandibular glands
(Pergamon-Elsevier Science Ltd, 2011-05)
Background: We demonstrated that serum immunoglobulin G (IgG) from patients with primary Sjögren's syndrome (pSS), interacting with the second extracellular loop of human glandular M3 muscarinic acetylcholine receptors (M3 ...
Chagasic antibodies induce cardiac COX-2/iNOS mRNA expression with PGE2/NO production
(Elsevier Ireland, 2009-05)
We demonstrate that serum IgG in chagasic patients interacting with the second extracellular loop of human cardiac M2 muscarinic acetylcholine receptors (M2 mAChR) trigger the production of PGE2 and NO, that in turn induces ...
Autoantibodies against cerebral muscarinic cholinoceptors in Sjögren syndrome: Functional and pathological implications
(Elsevier Science, 2004-05)
Previous studies have demonstrated that antibodies against muscarinic acetylcholine receptors (mAChRs) from exocrine glands, correlates with Sjögren syndrome (SS) in the majority of patients. The aim of the present ...
Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation
(Elsevier, 2020-09-05)
The cholinergic anti-inflammatory pathway has been shown to regulate lung inflammation and cytokine release in acute models of inflammation, mainly via α7 nicotinic receptor (α7nAChR). We aimed to evaluate the role of ...
Alteración de los niveles séricos del sistema enzimático antioxidante en pacientes con Síndrome de Sjögren primario y su relación con los autoanticuerpos anti-M3Alteration of serum levels of the anti-oxidant enzyme system in patients with primary Sjögren’s Syndrome and its relation with the anti-M3 autoantibodies
(Universidad de Morón, 2018-04)
El Síndrome de Sjögren (SS) es una enfermedad autoinmune crónica, de etiología desconocida, que afecta las glándulas exocrinas, cuya manifestación principal es la xeroftalmía y la xerostomía. Existen dos formas clínico-patológicas ...
Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis
(Elsevier Science, 2007-12)
The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, ...