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Cell life and death in the anterior pituitary gland: role of oestrogens
(Wiley, 2010-07)
Apoptotic processes play an important role in the maintenance of cell numbers in the anterior pituitary gland during physiological endocrine events. In this review, we summarise the regulation of apoptosis of anterior ...
Estradiol up-regulates c-FLIPlong expression in anterior pituitary cells
(Georg Thieme Verlag Kg, 2016-04)
Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior pituitary cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE ...
Estradiol Upregulates c-FLIPlong Expression in Anterior Pituitary Cells
(Georg Thieme Verlag Kg, 2016-04)
Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior pituitary cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE ...
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis
(Public Library Of Science, 2014-10)
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has ...
Intracellular distribution of GABA in the rat anterior pituitary. An electron microscopic autoradiographic study
(Harcourt Publishers, 2000-04)
We studied the internalization and intracellular distribution of [3H] GABA in rat anterior pituitary cells. Electron microscopic autoradiography of anterior pituitary fragments or dispersed pituitary cells incubated with[3H] ...
Programmed cell senescence: Role of IL-6 in the pituitary
(BioScientifica, 2017-05)
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, ...
Glutamate Induces Apoptosis in Anterior Pituitary Cells through Group II Metabotropic Glutamate Receptor Activation
(Endocrine Society, 2004-10)
Glutamate can induce neuronal cell death by activating ionotropic glutamate receptors (iGluRs) as well as metabotropic glutamate receptors (mGluRs). In the present study, we investigated whether glutamate induces apoptosis ...
In vivo and in vitro effects of chromium VI on anterior pituitary hormone release and cell viability
(Academic Press Inc Elsevier Science, 2007-12)
Hexavalent chromium (Cr VI) is a highly toxic metal and an environmental pollutant. Different studies indicate that Cr VI exposure adversely affects reproductive functions. This metal has been shown to affect several tissues ...
In vivo and in vitro arsenic exposition induces oxidative stress in anterior pituitary gland
(Sage Publications, 2016-04)
Inorganic arsenic (iAs) is at the top of toxic metalloids. Inorganic arsenic-contaminated water consumption is one of the greatest environmental health threats worldwide. Human iAs exposure has been associated with cancers ...
Nitric oxide plays a key role in ovariectomy-induced apoptosis in anterior pituitary: Interplay between nitric oxide pathway and estrogen
(Public Library of Science, 2016-09)
Changes in the estrogenic status produce deep changes in pituitary physiology, mainly because estrogens (E2) are one of the main regulators of pituitary cell population. Also, E2 negatively regulate pituitary neuronal ...