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Aminoglycoside modifying enzymes
(Churchill Livingstone, 2010-09)
Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and dissemination of resistance. In some ...
Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib
(Oxford University Press, 2021)
Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib, which encodes an AME that can confer resistance to some of the commercially ...
Generating genotype-specific aminoglycoside combinations with ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae
(American Society for Microbiology, 2021)
Antibiotic combinations, including ceftazidime/avibactam (CAZ/AVI), are frequently employed to combat KPC-producing Klebsiella pneumoniae (KPC-Kp), though such combinations have not been rationally optimized. Clinical ...
Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib
(Oxford University Press, 2021)
OBJECTIVES: KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib, which encodes an AME that can confer resistance to some of the commercially ...
Rise and dissemination of aminoglycoside resistance: the aac(6′)-Ib paradigm
(Frontiers, 2013-05)
Enzymatic modification is a prevalent mechanism by which bacteria defeat the action of antibiotics. Aminoglycosides are often inactivated by aminoglycoside modifying enzymes encoded by genes present in the chromosome, ...
Enzymatic resistance in pseudomonas aeruginosa, clinical and laboratory aspects
(2021)
Pseudomonas aeruginosa is one of the major pathogens causing healthcare-associated infections (HAI). Its capacity of adaptation, dissemination, intrinsic resistance to antimicrobials and of acquiring new mechanisms through ...
Elucidação estrutural da especificidade por substratos de enzimas da biossíntese de aminoglicosídeos e marginolactonas
(Universidade Estadual Paulista (Unesp), 2020-06-26)
Os produtos naturais desempenham um papel importante no desenvolvimento de medicamentos e parte desse sucesso está relacionado com a diversidade química e estrutural apresentadas pelos compostos dotados de relevância ...
Integron carrying a novel metallo-beta-lactamase gene, bla(IMP-16), and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': Report from the SENTRY antimicrobial surveillance program
(Amer Soc Microbiology, 2004-12-01)
Since January 2002 Pseudomonas sp. strains resistant to carbapenems and ceftazidime have been routinely screened as part of the SENTRY Antimicrobial Surveillance Program for metallo-beta-lactamase production, and their ...