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Pharmacogenetics: ethnicity, treatment and health in Latin American populations
(Future Medicine, 2023)
The Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) studies Latin American populations to benefit from the implementation of personalized medicine. Since 2006, it has studied ethnicity to apply ...
Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry
(PLoS, 2023)
Dental size variation in modern humans has been assessed from regional to worldwide scales, especially under microevolutionary and forensic contexts. Despite this, populations of mixed continental ancestry such as contemporary ...
Population genetics of PDE4B (Phosphodiesterase-4B) in neglected native americans: implications for cancer pharmacogenetics.
(Wiley, 2022)
PDE4B (phosphodiesterase-4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic ...
Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: Implications for South American prehistory
(BMC, 2014)
Background: Archaeology reports millenary cultural contacts between Peruvian Coast-Andes and the Amazon Yunga, a rainforest transitional region between Andes and Lower Amazonia. To clarify the relationships between cultural ...
Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: Implications for South American prehistory
(BioMed Central, 2014)
Background: Archaeology reports millenary cultural contacts between Peruvian Coast-Andes and the Amazon Yunga, a rainforest transitional region between Andes and Lower Amazonia. To clarify the relationships between cultural ...
Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population
(Public Library of Science, 2012)
Gastric cancer is one of the most lethal types of cancer and its incidence varies worldwide, with the Andean region of South America showing high incidence rates. We evaluated the genetic structure of the population from ...
Reconstructing Native American population history
(Springer Nature, 2012)
The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means ...
Demographic history and selection at HLA loci in Native Americans
(Public Library of Science, 2020)
The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this ...
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
(Brazilian Society of Genetics, 2021)
For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates ...