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Amantadine as a drug to mitigate the effects of COVID-19
The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent
the spread of coronavirus.
We are proposing amantadine as a drug that can be used to mitigate the effects ...
Amantadine improves gait in PD patients with STN stimulation
(Elsevier, 2013-03)
In advanced Parkinson´s disease (PD), axial symptoms such as speech, gait, and balance impairment often become levodopa-unresponsive and they are difficult to manage, even in patients with subthalamic nucleus deep brain ...
Interactions of the antiviral and antiparkinson agent amantadine with lipid membranes and human erythrocytes
(ELSEVIER SCIENCE BV, 2015)
Aimed to better understand the molecular mechanisms of its interactions with cell membranes, human erythrocyte and molecular models of the red cell membrane were utilized. The latter consisted of bilayers of dimyristoylp ...
Efficacy and safety of amantadine for the treatment of L-DOPA-induced dyskinesia
(Springer Wien, 2018-08)
l-DOPA induced dyskinesias (LIDs) may affect up to 40% of Parkinson’s disease (PD) and impact negatively health-related quality of life. Amantadine has demonstrated significant antidyskinetic effects in animal PD models ...
Utilization Patterns of Amantadine in Parkinson’s Disease Patients Enrolled in the French COPARK Study
(Adis Int Ltd, 2020-03)
Introduction: Immediate-release (IR) amantadine has been marketed for Parkinson’s disease (PD) therapy for 50 years, while two novel extended-release formulations have only recently reached the market in the US. Objectives: ...
In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides
(2021-09-15)
Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant
during recent outbreaks in Latin America due to its unrecognized association with fetal neurological
disorders. Currently, there ...
Case for diagnosis
(Sociedade Brasileira de Dermatologia, 2012-04-01)
Descreve-se caso clínico de paciente feminina adulta, portadora de doença de Parkinson em uso de amantadina que desenvolveu extenso quadro de livedo reticular nos membros e abdome após o início do medicamento. Discutem-se ...
Case for diagnosis
(Sociedade Brasileira de Dermatologia, 2012-04-01)
Descreve-se caso clínico de paciente feminina adulta, portadora de doença de Parkinson em uso de amantadina que desenvolveu extenso quadro de livedo reticular nos membros e abdome após o início do medicamento. Discutem-se ...
Re-treatment of previous non-responders and relapsers to interferon plus ribavirin with peginterferon alfa-2a (40KD), ribavirin +/- amantadine in patients with chronic hepatitis C: randomized multicentre clinical trial
(2012)
Introduction. A large number of patients with chronic hepatitis C have not been cured with interferon-based therapy. Therefore, we evaluated the efficacy of amantadine combined with the standard of care (pegylated interferon ...
Re-treatment of previous non-responders and relapsers to interferon plus ribavirin with peginterferon alfa-2a (40KD), ribavirin +/- amantadine in patients with chronic hepatitis C: randomized multicentre clinical trial
(Mexican Assoc Hepatology, 2012-01-01)
Introduction. A large number of patients with chronic hepatitis C have not been cured with interferon-based therapy. Therefore, we evaluated the efficacy of amantadine combined with the standard of care (pegylated interferon ...