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An intracellular arrangement of Histoplasma capsulatum yeast-aggregates generates nuclear damage to the cultured murine alveolar macrophages
(2016-01-01)
Histoplasma capsulatum is responsible for a human systemic mycosis that primarily affects lung tissue. Macrophages are the major effector cells in humans that respond to the fungus, and the development of respiratory disease ...
Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice
(Associação Brasileira de Divulgação Científica (ABRADIC), 2004-04-01)
Thalidomide is a selective inhibitor of tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in mycobacterial death mechanisms. We investigated the role of this drug in the functional activity of alveolar macrophages ...
Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
Phenotypic and functional characterization of innate immunity cells in the establishment of murine pulmonary malaria
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2021)
Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection
(2017-04-01)
Alveolar macrophages (AMs) are multitasking cells that maintain lung homeostasis by clearing apoptotic cells (efferocytosis) and performing antimicrobial effector functions. Different PRRs have been described to be involved ...
Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice
(Associação Brasileira de Divulgação Científica (ABRADIC), 2004-04-01)
Thalidomide is a selective inhibitor of tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in mycobacterial death mechanisms. We investigated the role of this drug in the functional activity of alveolar macrophages ...
Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages
(KARGER, 2010)
It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma. A role for LTs in innate immunity has recently emerged: Cys-LTs ...
Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages
(Karger, 2010-01-01)
It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma. A role for LTs in innate immunity has recently emerged: Cys-LTs ...
Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL1505
(Frontiers Media S.A., 2020-09-29)
The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the ...
Key role of TLR2 in the inflammatory response and MHC-II down-regulation in Brucella-infected alveolar macrophages
(American Society For Microbiology, 2014-02)
Alveolar macrophages (AM) seem to constitute the main cellular target of inhaled brucellae. Here we show that Brucella abortus invades and replicates in murine AM without inducing cytotoxicity. B. abortus infection induced ...