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Novel ALPL genetic alteration associated with an odontohypophosphatasia phenotype
(Elsevier Science IncNew YorkEUA, 2013)
Identificação da expressão das variantes 1 e 2 do gene que codifica a fosfatase alcalina em células tronco derivadas de tecido adiposo induzidas com dexametasonaIdentification of expression of variants 1 and 2 of the gene encoding alkaline phosphatase in dexamethasone-induced adipose tissue derived stem cells
(Universidade Federal do PampaUNIPAMPAMestrado Acadêmico em Ciências BiológicasBrasilCampus São Gabriel, 2019)
Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP)
(Wiley-Blackwell, 2002-01-01)
The D allozyme of placental alkaline phosphatase (PLAP) displays enzymatic properties at variance with those of the common PLAP allozymes. We have deduced the amino acid sequence of the PLAP D allele by PCR cloning of its ...
Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP)
(Wiley-Blackwell, 2002-01-01)
The D allozyme of placental alkaline phosphatase (PLAP) displays enzymatic properties at variance with those of the common PLAP allozymes. We have deduced the amino acid sequence of the PLAP D allele by PCR cloning of its ...
Enzyme replacement prevents enamel defects in hypophosphatasia mice
(WILEY-BLACKWELLHOBOKEN, 2012)
Hypophosphatasia (HPP) is the inborn error of metabolism characterized by deficiency of alkaline phosphatase activity, leading to rickets or osteomalacia and to dental defects. HPP occurs from loss-of-function mutations ...
Nanostructured hydroxyapatite networks: Synergy of physical and chemical cues to induce an osteogenic fate in an additive-free medium
(Elsevier, 2018-05-26)
Nanoscale topography plays a central role in adult-stem-cell-niches. In this study we have demonstrated that by an accurate material design, mimicking the composition and structure of bone extracellular matrix, it is ...