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Inoculation site from a cutaneous melanoma patient treated with an allogeneic therapeutic vaccine: A case report
(Frontiers Media S.A., 2015-04)
We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase ...
Tumor cell lysates as immunogenic sources for cancer vaccine design
(2014)
Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological memory generation. Nevertheless, ...
The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines
(Elsevier GmbH, 2006)
Immunotherapy has become a novel therapeutic alternative for various kinds of tumours. Recently, we have finalized the first phase I clinical study in Chile for the treatment of advanced malignant melanoma, using dendritic ...
An update of cutaneous melanoma patients treated in adjuvancy with the allogeneic melanoma vaccine vaccimel and presentation of a selected case report with in-transit metastases
(Frontiers Media, 2022-04)
The CSF-470 vaccine (VACCIMEL) plus BCG and GM-CSF as adjuvants has been assayed in cutaneous melanoma patients. In the adjuvant randomized Phase II study CASVAC-0401, vaccinated patients had longer distant metastasis-free ...
Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells
(2014)
We have previously reported a novel method for the production of tumour-antigen-presenting cells (referred to as TAPCells) that are currently being used in cancer therapy, using an allogeneic melanoma-derived cell lysate ...
Changes in the TCRβ repertoire and tumor immune signature from a cutaneous melanoma patient immunized with the CSF-470 vaccine: A case report
(Frontiers Media S.A., 2018-05)
The allogeneic therapeutic vaccine CSF-470 has demonstrated a significant benefit over medium-dose IFNa2b in the distant metastasis-free survival for stages IIB-IIC-III cutaneous melanoma patients in a randomized phase ...
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients
(2012)
Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells
(John Wiley & Sons Ltd,, 2014)
We have previously reported a novel method for the production of
tumour-antigen-presenting cells (referred to as TAPCells) that are currently
being used in cancer therapy, using an allogeneic melanomaderived
cell lysate ...
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
(Biomed Central Ltd., 2009-07-10)
The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant number of ...