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Inhibitory action on aldose reductase by soybean flavonoids
(Journal of the Brazilian Chemical Society, 2019)
QSAR prediction of inhibition of aldose reductase for flavonoids
(Pergamon-Elsevier Science Ltd, 2008-06)
We performed a predictive analysis based on quantitative structure–activity relationships (QSAR) of an important property of flavonoids, which is the inhibition (IC50) of aldose reductase (AR). The importance of AR inhibition ...
Regulation of aldose reductase activity by tubulin and phenolic acid derivates
(Elsevier Science Inc, 2018-09-15)
In this work we demonstrate that aldose reductase (AR) interacts directly with tubulin and, was subjected to microtubule formation conditions, enzymatic AR activity increased more than sixfold. Since AR interacts mainly ...
Aldose-6-phosphate reductase from apple leaves: Importance of the quaternary structure for enzyme activity
(Elsevier France-editions Scientifiques Medicales Elsevier, 2010-01)
Aldose-6-phosphate reductase (A6PRase) is a key enzyme for glucitol biosynthesis in plants from the Rosaceae family. To gain on molecular tools for enzymological studies, we developed an accurate system for the heterologous ...
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - differential effects of sorbitol and mannitol
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003)
Identifying and characterising putative aldose 6-phosphate reductases in Arabidopsis thaliana
(2017)
In Rosaceae (apple, stone fruits) and Plantaginaceae (plantain) species, sugar alcohols like sorbitol are phloem-translocated and allow more efficient use of carbon, act as compatible solutes in abiotic stress (cold, ...
Characterising AtA6PR2, a putative aldose 6-phosphate reductase in Arabidopsis thaliana
(2015)
In Plantaginaceae and Rosaceae species, sugar alcohols like sorbitol are phloem-translocated and allow more efficient use of carbon, act as compatible solutes in abiotic stress and facilitate boron mobilisation. The key ...
Identifying and characterising putative aldose 6-phosphate reductases in Arabidopsis thaliana
(2016)
In Rosaceae and Plantaginaceae species, sugar alcohols like sorbitol are phloem-translocated and allow more efficient use of carbon, act as compatible solutes in abiotic stress and facilitate boron mobilisation. The key ...