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Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to NO cytotoxicity
(Elsevier Science SA, 2005-09)
In this work, we studied the in vitro interactions between aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) and nitric oxide (NO), as well as the interactions between ALA, porphyrins and some NO donors and ...
Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: Tissue distribution
(Nature Publishing Group, 2003-02)
Although 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has proven to be clinically beneficial for the treatment of certain cancers, including a variety of skin cancers, optimal tissue localisation still ...
Porphyrin synthesis from ALA derivatives for photodynamic therapy: In vitro and in vivo studies
(Nature Publishing Group, 2004-03)
The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as ...
Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy
(Elsevier Science, 2009-04)
The use of endogenous protoporphyrin IX (PpIX) after administration of 5-aminolaevulinic acid (ALA) has led to many applications in photodynamic therapy (PDT). However the efficacy of ALA-PDT is sub-optimal for thicker ...
Scavengers protection of cells against ALA-based photodynamic therapy-induced damage
(Springer London Ltd, 2002-10)
The exogenously stimulated formation of intracellularly generated protoporphyrin IX, a precursor of haem, is becoming one of the fastest developing areas in the field of photodynamic therapy (PDT). We tested the action of ...
Fluorescence evaluations for porphyrin formation during topical PDT using ALA and methyl-ALA mixtures in pig skin models
(2016-09-01)
Background Photodynamic Therapy (PDT) using Aminolevulinic acid (ALA) and derivative molecules as topical medication and as a precursor of protoporphyrin (PPIX), is limited due to low permeation through skin or efficiency ...
In vitro assessment of anti-tumorigenic mechanisms and efficacy of NanoALA, a nanoformulation of aminolevulic acid designed for photodynamic therapy of cancer
(2017-12-01)
Background The development of nanocarriers is an important approach to increase the bioavailability of hydrophilic drugs in target cells. In this work, we evaluated the anti-tumorigenic mechanisms and efficacy of NanoALA, ...
Estudo histomorfométrico da necrose em tecido hepático de ratos: terapia fotodinâmica combinada com ablação a laser e terapia fotodinâmica com o fotossensibilizador Luzitin®
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Biotecnologia - PPGBiotec, 2012-11-08)
Photodynamic Therapy (PDT) is known to be limited to applications in large volume tumours due to its limited penetration. Therefore, the PDT with the Luzitin® photossensitizer as well as a combination of PDT and laser ...
Synthesis and characterization of aminolevulinic acid gold nanoparticles: Photo and sonosensitizer agent for atherosclerosis
(Elsevier Science Bv, 2018)
Photodynamic and sonodynamic therapies (PDT and SDT, respectively) are emerging as new atherosclerosis treatments. The subsequent generation of free radicals by activated photo and sonosensitizers can lead to apoptotic ...