Buscar
Mostrando ítems 1-10 de 104
Structural and kinetic studies of Schistosoma mansoni adenylate kinases
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
The human parasite Schistosoma mansoni is totally dependent on the purine salvage pathway in order to supply large quantities of purine precursors for its energy and DNA biosynthetic needs. Adenylate kinase (ADK) is ...
Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform
(Public Library Science, 2013-02-07)
Trypanosoma cruzi, the etiological agent of Chagas’ disease, is an early divergent eukaryote in which control of gene expression relies mainly in post-transcriptional mechanisms. Transcription levels are globally up and ...
The flagellar adenylate kinases of Trypanosoma cruzi
(Oxford University Press, 2015-01)
Adenylate kinases (ADK) are key enzymes involved in cell energy management. Trypanosomatids present the highest number of variants in a single cell in comparison with the rest of the living organisms. In this work, we ...
Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei
(American Society for Biochemistry and Molecular Biology, 2005-12)
Adenylate kinases occur classically as cytoplasmic and mitochondrial enzymes, but the expression of seven adenylate kinases in the flagellated protozoan parasite Trypanosoma brucei (order, Kinetoplastida; family, ...
Virtual screening of adenylate kinase 3 inhibitors employing pharmacophoric model, molecular docking, and molecular dynamics simulations as potential therapeutic target in chronic lymphocytic leukemia
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSHCL - HOSPITAL DAS CLINICASUFMG, 2021-12-03)
A adenilato quinase 3 (AK3) é uma enzima localizada na matriz mitocondrial envolvida na homeostase das purinas. Essa proteína tem sido considerada um potencial alvo terapêutico na leucemia linfocítica crônica (LLC), pois ...
Correlated Inter-Domain Motions in Adenylate Kinase
(Public Library Of Science, 2014-07)
Correlated inter-domain motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. Here we characterize at structural level the inter-domain coupling in a multidomain enzyme, ...
Hyaluronic acid capacitation induces intracellular signals modulated by membrane-associated adenylate cyclase and tyrosine kinase involved in bovine in vitro fertilization
(Elsevier Science Inc., 2020-05)
Heparin is the most commonly used in vitro capacitation inducer in the bovine. However, hyaluronic acid (HA) has been recently used for capacitation induction as well as for other reproductive biotechnologies, such as sperm ...