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Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy
(Bentham Science Publishers, 2013-04)
As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds ...
Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies
(2022)
Alzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the ...
Self-assembly of SiO2 nanoparticles for the potentiometric detection of neurotransmitter acetylcholine and its inhibitor
(American Scientific Publishers - ASPValencia, 2014-09)
The detection and quantification of neurotransmitter acetylcholine (ACh) are relevant because modifications in the ACh levels constitute a threat to human health. The biological regulator of this neurotransmitter is ...
ANTI-ALZHEIMER ACTIVITY OF SUBSTANCES FROM NATURAL PRODUCTS AND OF SYNTHETIC ORIGIN: SOME IMPORTANT EXAMPLES OF THE LAST 20 YEARS.
(Soc Brasileira Quimica, 2022-02-04)
Alzheimer's disease has about 9.9 million new cases annually, according to World Health Organization. Due to the increasing incidence of people affected by AD and the absence of an efficient treatment or cure so far, many ...
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Synthesis of novel 7-aryl and 7-spiropyrazolo[4 ',3 ':5,6]pyrido [2,3-d]pyrimidine derivatives and their study as AChE inhibitors
(2017)
An efficient route for the synthesis of novel 7-aryl and 7-spiropyrazolo[4', 3':5, 6]pyrido[2,3-d]pyrimidine derivatives is described. These compounds were obtained by a cyclocondensation reaction between pyrazolopyridinediamines ...
Caracterização da atividade da enzima acetilcolinesterase de veneno de bungarus sindanus: estudos comparativos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2008-03-10)
Acetylcholinesterase (AChE) belongs to a distinct family of serine hydrolases and is found in both synaptic and non-synaptic locations. At the synapses, it plays a major role
in the hydrolysis of the neurotransmitter ...
Glyphosate as an acetylcholinesterase inhibitor in Cnesterodon decemmaculatus
(Springer, 2012-01)
The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L -1) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. Acute bioassays (96 h) under ...
Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2010-05)
Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin selective reuptake inhibitors, on nicotinic acetylcholine receptors ...