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3 SUBTYPES OF ALPHA-BUNGAROTOXIN SENSITIVE NICOTINIC ACETYLCHOLINE-RECEPTORS ARE EXPRESSED IN CHICK RETINA
(Soc Neuroscience, 1993-02-01)
A recent report described the isolation of cDNA clones encoding alpha7 and alpha8 subunits of alpha-bungarotoxin-sensitive nicotinic ACh receptors (alphaBgtAChRs) from chick brain and demonstrated that they were related ...
A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors
(Wiley Blackwell Publishing, Inc, 2021-04)
The α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug ...
Differential Pharmacological Activity of JN403 between á7 and Muscle Nicotinic Acetylcholine Receptors
(American Chemical Society, 2013-10)
The differential action of the novel agonist JN403 at neuronalα7 and muscle nicotinic receptors (AChRs)was explored by using a combination of functional and structural approaches. Single-channel recordings reveal that JN403 ...
Activity of cytisine and its brominated isosteres on recombinant human a7, a4b2 and a4b4 nicotinic acetylcholine receptors
(International Society for Neurochemistry,, 2001-06-06)
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine
(5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on
human (h) a7-, a4b2- and a4b4 nicotinic acetylcholine (nACh)
receptors, expressed in Xenopus oocytes ...
Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro
(CHURCHILL LIVINGSTONE, 2008)
Muscarinic (mAChRs) and nicotinic acetylcholine receptors (nAChRs) are involved in various physiological processes, including neuronal development. We provide evidence for expression of functional nicotinic and muscarinic ...
Glutamine 57 at the Complementary Binding Site Face Is a Key Determinant of Morantel Selectivity for α7 Nicotinic Receptors
(American Society for Biochemistry and Molecular Biology, 2009-08)
Nicotinic receptors (AChRs) play key roles in synaptic transmission. We explored activation of neuronal alpha7 and mammalian muscle AChRs by morantel and oxantel. Our results revealed a novel action of morantel as a ...
Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function
(American Society for Pharmacology and Experimental Therapeutics, 2012-09-25)
Caenorhabditis elegans muscle contains seven different nicotinic receptor (AChR) subunits, five of which have been shown to be components of adult levamisole-sensitive AChRs (L-AChRs). To elucidate the reason for such ...
Neurotransmitter GABA Activates Muscle but not a7 Nicotinic Receptors
(American Society For Pharmacology And Experimental Therapeutics, 2015-03)
Cys-loop receptors are neurotransmitter-activated ion channels involved in synaptic and extrasynaptic transmission in the brain and are also present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR) belong ...
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
(American Society for Pharmacology and Experimental Therapeutics, 2006-12)
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs. The anthelmintic agents ...
Effects of acetylcholine and cholinergic antagonists on the activity of nucleus of the solitary tract neurons
(Elsevier B.V., 2017-03-15)
Previously we have demonstrated that microinjection of acetylcholine (ACh) into the intermediate nucleus of the solitary tract (iNTS) induced sympatho-inhibition combined with a decrease in the phrenic nerve activity (PNA), ...