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ACE gene polymorphism and severe lung injury in patients with COVID-19
COVID-19 has markedly varied clinical presentations, with the majority of patients being
asymptomatic or having mild symptoms. However, severe acute respiratory disease
caused by SARS-CoV-2 is common and associated with ...
Characterization of angiotensin-converting enzymes 1 and 2 in the soleus and plantaris muscles of rats
(Associação Brasileira de Divulgação Científica, 2010)
Angiotensin-converting enzymes 1 (ACE1) and 2 (ACE2) are key enzymes of the renin-angiotensin system, which act antagonistically to regulate the levels of angiotensin II (Ang II) and Ang-(1-7). Considerable data show that ...
ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser(1270)
(PUBLIC LIBRARY SCIENCE, 2011)
Objectives: We tested whether angiotensin converting enzyme (ACE) and phosphorylation of Ser(1270) are involved in shear-stress (SS)-induced downregulation of the enzyme. Methods and Results: Western blotting analysis ...
ACE2, the Receptor that Enables the Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators
(Wiley VCH Verlag, 2020-07)
Angiotensin Converting Enzyme 2 (ACE2) is the human receptor that interacts with the Spike protein of coronaviruses, including the one that produced the 2020 coronavirus pandemic (COVID-19). Thus, ACE2 is a potential target ...
Renin-angiotensin system may trigger kidney damage in NOD mice
(Sage Publications Ltd, 2011-03-01)
Diabetic nephropathy is a complication of diabetes and one of the main causes of end-stage renal disease. A possible causal link between renin-angiotensin aldosterone system (RAAS) and diabetes is widely recognized but the ...
Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture
(Lippincott Williams & Wilkins, 1998-12-01)
Objective Previous analysis of the angiotensin I-converting enzyme (ACE) gene in this laboratory showed that primary mesangial cells in culture are able to express ACE mRNA. Moreover, ACE is produced as an ectoenzyme and ...
Ace gene dosage influences the development of renovascular hypertension
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
P>1. Clinical and experimental evidence highlights the importance of the renin-angiotensin system in renovascular hypertension. Furthermore, genetic factors affecting angiotensin-converting enzyme (ACE) could influence the ...
ACE2 a double-edged sword?
(2020)
Rapport Projet Challenge Entreprises Ace Manager BNP Paribas
(Universidad del RosarioAdministrador de negocios internacionalesFacultad de administración, 2013)
Financial Analysis of several cases proposed by the bank BNP Paribas as part of their semestral competition, Ace Manger. BNP Paribas is the first one in the euro zone and the sixth bank worldwide. For the development of ...
Association of angiotensin-converting enzyme activity and polymorphism with echocardiographic measures in familial and nonfamilial hypertrophic cardiomyopathy
(Associação Brasileira de Divulgação Científica, 2009)
Angiotensin-converting enzyme (ACE) activity and polymorphism contribute significantly to the prognosis of patients with cardiomyopathy. The aim of this study was to determine the activity and type of ACE polymorphism in ...