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Characterization of angiotensin-converting enzymes 1 and 2 in the soleus and plantaris muscles of rats
(Associação Brasileira de Divulgação Científica, 2010)
Angiotensin-converting enzymes 1 (ACE1) and 2 (ACE2) are key enzymes of the renin-angiotensin system, which act antagonistically to regulate the levels of angiotensin II (Ang II) and Ang-(1-7). Considerable data show that ...
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to macrophage activation syndrome: Therapeutic implications
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international scientific community has joined forces to develop effective treatment strategies. The Angiotensin-Converting Enzyme (ACE) 2,
is ...
Association of angiotensin-converting enzyme activity and polymorphism with echocardiographic measures in familial and nonfamilial hypertrophic cardiomyopathy
(Associação Brasileira de Divulgação Científica, 2009)
Angiotensin-converting enzyme (ACE) activity and polymorphism contribute significantly to the prognosis of patients with cardiomyopathy. The aim of this study was to determine the activity and type of ACE polymorphism in ...
ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser(1270)
(PUBLIC LIBRARY SCIENCE, 2011)
Objectives: We tested whether angiotensin converting enzyme (ACE) and phosphorylation of Ser(1270) are involved in shear-stress (SS)-induced downregulation of the enzyme. Methods and Results: Western blotting analysis ...
Lima Bean (Phaseolus lunatus) Protein Hydrolysates with ACE-I Inhibitory Activity
(2013-01-30)
Several protein sources can be used to produce bioactive peptides with angiotensin I-converting enzyme (ACE) inhibit- tory activity. Protein concentrates from ungerminated and germinated lima bean Phaseolus lunatus seed ...
Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans
(NATURE PUBLISHING GROUP, 2004-02)
Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(17)]. In humans, the insertion/deletion (I/D) angiotensin- I converting enzyme ( ACE) gene polymorphism determined ...
Renin-angiotensin system may trigger kidney damage in NOD mice
(Sage Publications Ltd, 2011-03-01)
Diabetic nephropathy is a complication of diabetes and one of the main causes of end-stage renal disease. A possible causal link between renin-angiotensin aldosterone system (RAAS) and diabetes is widely recognized but the ...
ACE2, the Receptor that Enables the Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators
(Wiley VCH Verlag, 2020-07)
Angiotensin Converting Enzyme 2 (ACE2) is the human receptor that interacts with the Spike protein of coronaviruses, including the one that produced the 2020 coronavirus pandemic (COVID-19). Thus, ACE2 is a potential target ...
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?
(Oxford University Press, 2020-07-22)
Background
Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with healthy control (HC) volunteers, and the relevance of combining ACE genotype ...
Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
(LIPPINCOTT WILLIAMS & WILKINS, 2001-09)
Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ...