Buscar
Mostrando ítems 1-10 de 274
New frameshift mutation in the 5 alpha-reductase type 2 gene in a Brazilian patient with 5 alpha-reductase deficiency
(Wiley-lissNew YorkEUA, 1999)
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-01-30)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Design, synthesis, and docking of highly hypolipidemic agents:Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-02-26)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects
(Elsevier B.V., 2005-09-01)
The present study was carried out to determine whether 5alpha-reductase 2 (5alpha-R2) metabolic pathway plays a key role in brain sexual differentiation. The inhibition of 5alpha-R2 by finasteride (20 mg/kg/day) from ...
5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects
(Elsevier B.V., 2005-09-01)
The present study was carried out to determine whether 5alpha-reductase 2 (5alpha-R2) metabolic pathway plays a key role in brain sexual differentiation. The inhibition of 5alpha-R2 by finasteride (20 mg/kg/day) from ...
Diagnosis of 5 alpha-reductase type 2 deficiency: Contribution of anti-Mullerian hormone evaluation
(Walter De Gruyter Gmbh, 2005-01-01)
Aim: To evaluate anti-Mullerian hormone (AMH) levels in patients with clinical and molecular diagnosis of 5 alpha-reductase 2 deficiency. Patients and Methods: Data from 14 patients whose age ranged from 21 days to 29 years ...
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
(HUMANA PRESS INC, 2010)
Cortisol availability is modulated by several enzymes: 11 beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11 beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases ...