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New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents
(Royal Society of Chemistry, 2019-04-15)
In the search for a more effective chemotherapy for the treatment of Chagas´ disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic ...
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets
(AMER CHEMICAL SOC, 2006-06-01)
In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones
(Springer, 2013)
In the search for new metal-based drugs against
diseases produced by trypanosomatid parasites, four
organoruthenium(II) compounds [Ru2(p-cymene)2(L)2]
X2, where L are bioactive 5-nitrofuryl-containing
thiosemicarbazones ...
Water-Soluble Ruthenium Complexes Bearing Activity Against Protozoan Parasites
(Springer, 2014)
Parasitic illnesses are major causes of human disease
and misery worldwide. Among them, both amebiasis and
Chagas disease, caused by the protozoan parasites, Entamoeba
histolytica and Trypanosoma cruzi, are responsible ...