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Cold-induced PGC-1 alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway
(Amer Physiological SocBethesdaEUA, 2004)
Thyroid hormone activates rat liver adenosine 5-monophosphate-activated protein kinase: Relation to CaMKKβ, TAK1, and LKB1 expression and energy status
(2013)
AMP-activated protein kinase (AMPK) is a sensor of energy status supporting cellular energy homeostasis that may represent the metabolic basis for 3,3′,5-triiodo-L-thyronine (T3) liver preconditioning. Functionally transient ...
Contraction-related stimuli regulate GLUT4 traffic in C2C 12-GLUT4myc skeletal muscle cells
(2010)
Muscle contraction stimulates glucose uptake acutely to increase energy supply, but suitable cellular models that faithfully reproduce this complex phenomenon are lacking. To this end, we have developed a cellular model ...
Signal transduction pathways in FSH regulation of rat sertoli cell proliferation
(American Physiological Society, 2012-04)
The final number of Sertoli cells reached during the proliferative periods determines sperm production capacity in adulthood. It is well known that FSH is the major Sertoli cell mitogen; however, little is known about the ...
Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge
(AMER PHYSIOLOGICAL SOC, 2011)
Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. Am J Physiol Endocrinol Metab 300: E858-E869, 2011. First published February 22, 2011; doi: 10.1152/ajpendo.00558.2010.-Acute ...
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia
(Endocrine SocChevy ChaseEUA, 2007)
The isatin-Schiff base copper(II) complex Cu(isaepy)(2) acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis
(OXFORD UNIV PRESS, 2009)
We previously demonstrated that Bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl) pyridine-N, N`] copper(II) [Cu(isaepy)(2)] was an efficient inducer of the apoptotic mitochondrial pathway. Here, we deeply dissect the mechanisms ...
Metabolic basis for thyroid hormone liver preconditioning: Upregulation of AMP-activated protein kinase signaling
(2012)
The liver is a major organ responsible for most functions of cellular metabolism and a mediator between dietary and endogenous sources of energy for extrahepatic tissues. In this context, adenosine-monophosphate- (AMP-) ...