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4-Methylumbelliferone as a potent and selective antitumor drug on a glioblastoma model
(Oxford Univ Press Inc, 2021-01)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor ...
4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis
(Oxford University Press, 2015-08)
Cirrhosis is characterized by an excessive accumulation of extracellular matrix components including hyaluronic acid (HA) and is widely considered a pre-neoplastic condition for hepatocellular carcinoma (HCC). 4-methylum ...
Targeting the tumor extracellular matrix by the natural molecule 4-Methylumbelliferone: a complementary and alternative cancer therapeutic strategy
(Frontiers Media, 2021-10)
In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of each patient and reduce the toxicity caused by conventional antitumor strategies. It has been demonstrated that natural products ...
Improving arylsulfatase activity determination in dried blood spots: screening and diagnostic approaches for Maroteaux–Lamy syndrome (MPS VI)
(Elsevier, 2015-06)
BACKGROUND: Mucopolysaccharidosis type VI can be screened by measuring the lysosomal arylsulfatase B (ARSB) residual enzyme activity in dried blood spots (DBS) using synthetic substrates. However, we have found experimental ...
4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines
(Springer, 2016-10)
Chronic myeloid leukemia (CML) is a myeloproliferative syndrome characterizedby the presence of the Philadelphia chromosome which encodes a constitutivelyactivated tyrosine kinase (BCRABL).The first line treatment for CML ...
Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis
(Nature, 2019-03)
Hyaluronic acid (HA) is a glycosaminoglycan of extracellular matrix related to cell surface which interacts with various cell types. To understand the role of HA during hepatocarcinogenesis, we assessed the effect of the ...
Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation
(Nature Publishing Group, 2021-12)
The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with ...
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
(Nature, 2021-12)
Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ...