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The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020
3CLpro is a key enzyme for the maturation of all coronaviruses and has hence
been recognized as a potent drug target for the treatment of coronavirus infection. The
present review focuses on the status of various efficacious ...
A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main Protease
(2022-01-24)
The SARS-CoV-2 main protease, also known as 3-chymotrypsin-like protease (3CLpro), is a cysteine protease responsible for the cleavage of viral polyproteins pp1a and pp1ab, at least, at eleven conserved sites, which leads ...
Lopinavir/ritonavir: repurposing an old drug for HIV infection in COVID-19 treatment
Currently, there is no specific antiviral treatment for COVID-19. However, drugs previously
developed to treat other viral infections are being tested to verify if they might also be effective
against SARS-CoV-2, the ...
Proteasas del SARS-CoV-2 como blanco farmacológico. Revisión bibliográfica y ensayo enzimático
(Udelar. FM, 2022)
Las proteasas “main protease” (M-pro o 3CL-pro) y “papain-like protease” (PL-pro) del SARS-CoV-2 son fundamentales en el ciclo replicativo del virus. En base a esto, las mismas han sido propuestas como blanco terapéutico ...
Estudio bibliográfico comparativo de actividad antiviral del eucalipto Eucalyptus globulus y ajo Allium sativum para pacientes con Sars Cov 2
(Universidad de Guayaquil. Facultad de Ciencias Químicas, 2021)
Actualmente a nivel mundial, el COVID-19 representa una amenaza para las organizaciones mundiales de la salud ya que ha causado aproximadamente un índice de mortalidad de 15% en todo el mundo debido a la severidad de los ...