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Regulation of aldose reductase activity by tubulin and phenolic acid derivates
(Elsevier Science Inc, 2018-09-15)
In this work we demonstrate that aldose reductase (AR) interacts directly with tubulin and, was subjected to microtubule formation conditions, enzymatic AR activity increased more than sixfold. Since AR interacts mainly ...
Sodium nitrite attenuates hypertension-in-pregnancy and blunts increases in soluble fms-like tyrosine kinase-1 and in vascular endothelial growth factor
(2016-07-01)
Preeclampsia is a pregnancy-associated disorder characterized by hypertension with uncertain pathogenesis. Increases in antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and reductions in nitric oxide (NO) ...
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats
(2016-12-01)
Sodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental ...
Case report: Maternal tyrosinemia type 1a under NTBC treatment with tyrosine- and phenylalanine restricted diet in Chile
(Wiley, 2020)
We report the case of a 17-year-old girl with Tyrosinemia type 1a who carried a planned pregnancy to
term while being under 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC, nitisinone)
treatment and a ...
A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway
(ELSEVIER SCIENCE BV, 2008)
There is evidence that nitric oxide plays a role in the neurotransmitter balance within the basal ganglia and in the pathology of Parkinson`s disease. In the present work we investigated in striatal 6-hydroxydopamine ...
Hypertension, augmented activity of matrix metalloproteinases-2 and -9 and angiogenic imbalance in hypertensive pregnancy are attenuated by doxycycline
(2018-12-05)
Preeclampsia is manifested as maternal hypertension and fetal growth restriction. Matrix metalloproteinases (MMPs) are involved in hypertension and doxycycline reduces blood pressure by inhibition of MMPs. Moreover, excessive ...
Midgut epithelial responses of different mosquito-Plasmodium combinations: the actin cone zipper repair mechanism in Aedes aegypti
(The National Academy of Sciences, 2013)
Impaired HPA axis function in diabetes involves adrenal apoptosis and phagocytosis
(Humana Press, 2019-03)
Purpose: The aim of the present study was to analyze the involvement of oxidative stress and inflammation in the modulation of glucocorticoid production in the adrenal cortex of diabetic rats. Methods: Male Wistar rats ...
Efeitos da doxiciclina relacionados à inibição das metaloproteinases em modelo de pré-eclâmpsia induzida por l-name em ratas
(Universidade Estadual Paulista (Unesp), 2018-12-05)
O óxido nítrico (NO) é um gás produzido principalmente por células endoteliais, e durante a época gestacional, contribui para evitar aumento exacerbado da resistência vascular sistêmica (RVS), uma vez que, durante esse ...
Flavonoides de Bunchosia armeniaca e derivados de 2-arilideno-1-a-tetralona
(Florianópolis, SC, 2012)