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Intracranial Pressure During the Development of Renovascular Hypertension
(Lippincott Williams & Wilkins, 2021-04-01)
The mechanisms by which changes in intracranial pressure (ICP) occur during hypertension are unclear. The experimental 2K1C (2-kidney, 1-clip) hypertension is a model characterized by sympathetic and renin-angiotensin ...
Increased Na, K, Cl cotransporter and Na, K-ATPase activity of vascular tissue in two-kidney Goldblatt hypertension
(1998)
The properties of the Na/K pump and Na, K, Cl cotransporter were studied in vascular tissue of two-kidney Goldblatt hypertensive rats. These transport systems were measured as ouabain-sensitive and bumetanide-sensitive ...
Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension
(SPRINGER, 2011)
The vascular remodeling associated with hypertension involves oxidative stress and enhanced matrix metalloproteinases (MMPs) expression/activity, especially MMP-2. While previous work showed that lercanidipine, a ...
Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: Therapeutic implications in human hypertension
(2014)
Oxidative stress (OS) plays a key role in the pathophysiology of essential hypertension and is associated with changes in the cell membrane fatty acid composition and fluidity. As (Na,K)-ATPase is modulated by the surrounding ...
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
(1983-01-01)
The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the ...
Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol
(2015)
Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin’s effects. The present study aimed to analyze and compare the effects of these two vasoconstrictors, ...
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenololImpacto do tabagismo passivo na resposta pressórica à epinefrina e felipressina em ratos hipertensos 1k1c tratados ou não com atenolol
(2020-02-01)
Background: Cigarette smoking is usually associated with hypertension and may modify vasoconstrictor response. Objective: The present study aimed to analyze and compare the interaction of passive cigarette smoking and ...
Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension
(ELSEVIER SCIENCE INC, 2009)
Mounting evidence indicates that structural and functional vascular changes associated with two-kidney, one-clip (2K-1C) hypertension result, at least in part, from altered activity of matrix metalloproteinases (MMPs). ...
Sympathetic overactivity occurs before hypertension in the two-kidney, one-clip model
(Wiley-blackwell, 2016)
Our knowledge of mechanisms responsible for both the development and the maintenance of hypertension remains incomplete in the Goldblatt (two-kidney, one-clip