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Increased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate.

Nunes, Valéria S; Panzoldo, Natália B; Leança, Camila C; Parra, Eliane S; Zago, Vanessa S; da Silva, Eliton J; Cazita, Patrícia M; Nakandakare, Edna R; de Faria, Eliana C; Quintão, Eder C R (2014)

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Marcello, Alessandro; Civra, Andrea; Milan Bonotto, Rafaela; Nascimento Alves, Lais; Rajasekharan, Sreejith; Giacobone, Chiara; Caccia, Claudio; Cavalli, Roberta; Adami, Marco; Brambilla, Paolo; Lembo, David; Poli, Giuseppe; Leoni, Valerio

There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of ...

24S‐hydroxycholesterol: cellular effects and variations in brain diseases

Sodero, Alejandro Omar (Wiley Blackwell Publishing, Inc, 2020-05)

The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or ...

Combining 25-hydroxycholesterol with an HIV fusion inhibitor peptide: Interaction with biomembrane model systems and human blood cells

Gomes, Bárbara; Sanna, Giusepinna; Madeddu, Silvia; Hollmann, Axel; Santos, Nuno C. (American Chemical Society, 2019-02-28)

The fusion between the viral and the target cell membrane is a crucial step in the life cycle of enveloped viruses. The blocking of this process is a well-known therapeutic approach that led to the development of the fusion ...

Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition

Gomes, Bárbara; Gonçalves, Sónia; Disalvo, Edgardo Anibal; Hollmann, Axel; Santos, Nuno C. (Elsevier Science, 2018-05)

Recently, it was demonstrated that 25-hydroxycholesterol (25HC), an oxidized cholesterol derivative, inhibits human immunodeficiency virus type 1 (HIV) entry into its target cells. However, the mechanisms involved in this ...

PROLIFERATION OF MAMMARY CELLS AFTER EXPOSURE TO 27 HYDROXYCHOLESTEROL, A NOVEL SELECTIVE MODULATOR OF ESTROGEN RECEPTORS (SERM).

Universidad de Chile (2009)

27-hydroxycholesterol induces the transition of mcf7 cells into a mesenchymal phenotype

Autor desconocido (SPANDIDOS PUBL LTD, 2011)

Identificação e quantificação de oxisteróis em ateromas e plasma de indivíduos com doença arterial periférica oclusiva submetidos à cirurgia de amputaçãoIdentification and quantification of oxysterols in atheromas and plasma of individuals with occlusive peripheral arterial disease submitted to amputation surgery

Virginio, Vitor Wilson de Moura, 1989- ([s.n.], 2014)

24S-hydroxycholesterol: cellular effects and variations in brain diseases

Sodero, Alejandro O. (Wiley, 2020)

Abstract The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 ...

Regulation of inhibin/activin expression in rat early antral follicles

Andreone, Luz; Velásquez, Ethel V.; Abramovich, Dalhia Nurit; Ambao, Veronica Ana; Loreti, Rosana Nazareth; Croxatto, Horacio B.; Parborell, Maria Fernanda Agustina; Tesone, Marta; Campo, Stella Maris (Elsevier Ireland, 2009-10)

The aim of the present study was to determine the endocrine activity of cultured early antral follicles (EAF) isolated from prepubertal diethylstilbestrol-treated rats. The effect of steroidogenic substrates and FSH on ...

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