Buscar
Mostrando ítems 1-10 de 45
Catalytic O- to N-Alkyl Migratory Rearrangement: Transition Metal-Free Direct and Tandem Routes to N-Alkylated Pyridones and Benzothiazolones
(2018-01-01)
The present study reports the synthesis of N-alkylated pyridones and benzothiazolones via O- to N-alkyl group migration under transition metal-free TfOH-catalyzed reaction conditions for the first time, to the best of our ...
New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists
(MDPI, 2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
New pyridone-based derivatives as cannabinoid receptor type 2 agonists
(MDPI, 2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
Biomimetic Domino Knoevenagel/Cycloisomerization Strategy for the Synthesis of Citridone A and Derivatives
(American Chemical Society, 2021-09)
Studies on Knoevenagel condensations between conjugated dienals and 4-hydroxy-2-pyridone/quinolone-type 1,3-dicarbonyl equivalents led to the development of a simple one-pot strategy to access citridone A and related ...
Reaction of acyclic enaminones with methoxymethylene meldrum's acid. Synthetic and structural implications
(Brasil, 2003)
The reaction of acyclic enaminones with methoxymethylene Meldrum's acid afforded N-adduct and/or C-adduct of enaminones in moderate to good yields. The regiochemistry of this reaction depends on the N-amino substituent of ...
The addition of 2-tert-butyldimethylsilyloxyfuran to cyclic N-acyliminium ions containing cyclohexyl-based chiral auxiliaries
(Pergamon-elsevier Science LtdOxfordInglaterra, 2000)
New Cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system: A chemical approach
(Academic Press, 2023)
The modulation of the endocannabinoid system by synthetic ligands has allowed mediating several pathophysiological processes in the control of various diseases. The work of many chemists in designing drugs that activate ...