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Rapid determination of retinoic acid and its main isomers in plasma by second order high-performance liquid chromatography data modeling
(Springer Heidelberg, 2014-11)
This paper reports the development of a method based on high-performance liquid chromatography (HPLC) coupled to second-order data modeling with multivariate curve resolution-alternating least-squares (MCR–ALS) for ...
Determination of isotretinoin (13-cis-retinoic acid) using a sensor based on reduced graphene oxide modified with copper nanoparticles
(2020-01-01)
The electrochemical behaviour of isotretinoin (13-cis-RA) on an electrode modified with a composite based on reduced graphene oxide (rGO) modified with copper nanoparticles (CuNPs) was investigated. The rGO-CuNPs composite ...
Isotretinoin Oxidation and Electroanalysis in a Pharmaceutical Drug Using a Boron-doped Diamond Electrode
(2016-11-01)
Isotretinoin redox behaviour, by voltammetry, at the cathodic pre-treated boron doped diamond electrode by cyclic, differential pulse and square wave voltammetry, and by spectrophotometry in a wide pH range, was investigated. ...
Cardiac remodeling induced by 13-cis retinoic acid treatment in acne patients
(2013-02-10)
Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Cardiac remodeling induced by 13-cis retinoic acid treatment in acne patients
(2013-02-10)
Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Plasma retinoids concentration in Leptodactylus chaquensis (Amphibia: Leptodactylidae) from rice agroecosystems, Santa Fe province, Argentina
(Pergamon-Elsevier Science Ltd, 2015-04)
Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis of vertebrates: Alteration in endogenous retinoids concentration is linked with teratogenic effects. Retinol (ROH), ...
Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2
(2005)
Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B
cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high ...
Desarrollo de estrategias analíticas basadas en técnicas cromatográficas y modelado quimiométrico para la determinación de ácido retinoico y principios activos de uso veterinario en muestras de interés biológico
(17-12-04)
El capítulo uno contiene el desarrollo de métodos para la determinación de ácido retinoico en plasma de Leptodactylus chaquensis y pacientes dermatológicos en tratamiento con Isotretinoína Roaccutan. El uso de diseño de ...
Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines
(2006)
Two retinoids, ATRA and 13cisRA, were incorporated into liposomes of different composition and charge and added to two hepatoma cell lines with different degree of transformation to measure cytotoxicity by MTT assay.
...