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Synthesis of 1α,25-Dihydroxyvitamin D3 Analogues with α-Hydroxyalkyl Substituents at C12
(2013)
Convergent syntheses of three new analogues of 1α,25-dihydroxyvitamin D3 with α-hydroxyalkyl substituents at C12 (4a–c) are described. The A-ring and triene system of each analogue were assembled by a tandem Pd-catalysed ...
Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation
(2020-03-12)
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that involves damage to the myelin sheath surrounding axons. MS therapy is based on immunomodulatory drugs that reduce disease recurrence ...
Cell Differentiation and Bone Protein Synthesis in the Lungs of Sheep with Spontaneous Calcinosis
(Elsevier, 2000-11)
The lungs of three sheep with spontaneous enzootic calcinosis induced by the calcinogenic plantNierembergia veitchii (Nv) were examined electron microscopically and immunohistochemically. The main ultrastructural changes ...
Role of VDR in 1α,25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs, Src and Akt in skeletal muscle cells
(Elsevier, 2013-07)
1,25-dihydroxyvitamin D3 [1,25D] is recognized as a steroid hormone that rapidly elicits intracellular signals in various tissues. In skeletal myoblasts, we have previously demonstrated that one of the 1,25Dinduced non-genomic ...