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Racemic salsolinol and its enantiomers act as agonists of the µ-opioid receptor by activating the Gi protein-adenylate cyclase pathway
(Frontiers Media S.A., 2017)
© 2017 Berríos-Cárcamo, Quintanilla, Herrera-Marschitz, Vasiliou, Zapata-Torres and Rivera-Meza. Background: Several studies have shown that the ethanol-derived metabolite salsolinol (SAL) can activate the mesolimbic system, ...
Activation of μ opioid receptors in the LPBN facilitates sodium intake in rats
(2015)
Important inhibitory mechanisms for the control of water and sodium intake are present in the lateral parabrachial nucleus (LPBN). Opioid receptors are expressed by LPBN neurons and injections of endorphin (nonspecific ...
Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site
(Blackwell Publishing Ltd, 2019)
(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
Mecanismos envolvendo receptores opióides μ do núcleo parabraquial lateral no controle da ingestão de água e sódio
(Universidade Estadual Paulista (Unesp), 2012)
No sistema nervoso central (SNC), mecanismos excitatórios e inibitórios atuam para controlar a ingestão de água e sódio. Importantes mecanismos inibitórios da ingestão de água e sódio foram recentemente descobertos no ...
Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol-mediated aversive learning, and affects μ but not δ or κ opioid receptor mRNA expression
(Wiley Blackwell Publishing, Inc, 2015-04)
Animal models of prenatal ethanol exposure (PEE) have indicated a facilitatory effect of PEE on adolescent ethanol intake, but few studies have assessed the effects of moderate PEE throughout adolescence. The mechanisms ...