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Production of β-lactamase inhibitors by Streptomyces species
(2018-09-01)
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials ...
Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru
(MDPI, 2021)
Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment ...
Identificação de metalo-β-lactamases em bacilos gram-negativos não fermentadores isolados no Hospital Universitário de Santa Maria
(Universidade Federal de Santa MariaBRAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências Farmacêuticas, 2008-01-18)
In recent years, the isolation of bacteria producing β-lactamases has caused concern around the world, due to the fact these enzymes hydrolysis the ring β-lactam antimicrobials used in the main clinic. This aim of this ...
Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution
(MDPI, 2014-07)
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a ...
Draft Genome Sequence of the First New Delhi Metallo-β-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru
(American Society for Microbiology, 2018)
We present here the draft genome sequence of the first New Delhi metallo-β-lactamase (NDM-1)-producing Escherichia coli strain, belonging to sequence type 155 (ST155), isolated in Peru. Assembly of this draft genome resulted ...
In silico mutations of TEM-1 β-lactamase show changes in structure and drug-enzyme affinity binding by molecular docking
(2016)
Bacterial resistance refers to bacteria capacity to evade antibiotic action, which constitutes a public
health issue. This resistance is given by β-lactamase enzymes that break the drug rings and alter its function. To ...
Draft genome sequence of a New Delhi Metallo-β-Lactamase (NDM-1)-Producing providencia stuartii strain isolated in Lima, Peru
(American Society for Microbiology, 2020)
Providencia stuartii is an opportunistic pathogen of the Enterobacteriales order. Here, we report the 4,594,658-bp draft genome sequence of a New Delhi metallo-β-lactamase (NDM-1)-producing Providencia stuartii strain that ...
Global high-risk clone of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae ST307 emerging in livestock in Peru
(Elsevier, 2021)
Klebsiella pneumoniae is a nosocomial pathogen with pandemic lineages threatening public health worldwide. Extended-spectrum B-lactamase (ESBL)- producing K. pneumoniae belonging to sequence type 307(ST307) is an emerging ...