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Immunosensor for diagnosis of Alzheimer disease using amyloid-β 1-40 peptide and silk fibroin thin films
(2016-11-01)
Layer-by-Layer (LbL) films containing silk fibroin (SF) and the 40 aminoacid-long amyloid-β peptide (Aβ1-40) were prepared with the purpose of developing a new prototype of an electrochemical immunosensor. The film showed ...
Small Molecule Inhibitors of Lysozyme Amyloid Aggregation
(Springer, 2020)
Distinct conformational states of the Alzheimer β-amyloid peptide can be detected by high-pressure NMR spectroscopy
(Wiley-VCH VerlagWeinheim, 2013-08)
Folding under pressure: High-pressure NMR spectroscopy detects three different conformational states of the Aβ-peptide in solution: a compactly folded state 1, a partially folded state 2′, and a random-coil like state 2′′ ...
Securinine derivatives as potential anti-amyloid therapeutic approach
(Bentham Science Publishers B.V., 2017)
β-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
(2008)
Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. Synaptic dysfunction is an early manifestation of AD. The cellular mechanism by which β-amyloid ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...
Self-assembly and anti-amyloid cytotoxicity activity of amyloid beta peptide derivatives
(Nature Publishing Group, 2017-03)
The self-assembly of two derivatives of KLVFF, a fragment Aβ(16-20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1-42) is observed at sub-stoichiometric ...