Buscar
Mostrando ítems 1-10 de 63
α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
(2006)
α4 and β2 nicotinic acetylcholine receptor (nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on the α4 to ...
Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes
(American Chemical Society, 2018-04)
The drimane sesquiterpenoids drimenin, cinnamolide, dendocarbin A, and polygodial were purified from the Canelo tree (Drimys winteri) and chemically characterized by spectroscopic methods. The pharmacological activity of ...
A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors
(Wiley Blackwell Publishing, Inc, 2021-04)
The α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug ...
Síntesis de compuestos neo-nicotínicos con afinidad a los receptores nicotínicos α4β2 y a los transportadores de serotonina y dopaminaSynthesis of neo-nicotinic compounds with affinity for α4β2 nicotinic receptors and serotonin and dopamine transporters
(2020)
Durante las últimas décadas, los receptores nicotínicos de acetilcolina (RnACh), los transportadores de serotonina (TSER) y los transportadores de dopamina (TDA), han sido los principales blancos de estudio para el desarrollo ...
Non-equivalent ligand selectivity of agonist sites in (α4β2) 2α4 nicotinic acetylcholine receptors: A key determinant of agonist efficacy
(American Society for Biochemistry and Molecular Biology Inc., 2014)
The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant nAChR type in the brain, and this receptor type exists in alternate (α4β2)2α4 and (α4β2)2β2 forms, which are activated by agonists with strikingly ...
Antagonistas de los receptores de acetilcolina nicotínicos α4β2 reducen el consumo de etanol en el modelo de rata bebedora UChB.Antagonists of nicotinic acetylcholine receptors α4β2 reduce ethanol consumption in the high-drinking model UChB rat.
(2019)
Introducción y propuesta: La literatura acumulada sugiere que los receptores de acetilcolina nicotínicos (nAChRs) de subtipo α4β2 pueden ser considerados como blancos farmacológicos para el tratamiento de abuso de alcohol. ...
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
(National Academy of Sciences, 2001-03)
We report the cloning and characterization of rat α10, a previously unidentified member of the nicotinic acetylcholine receptor (nAChR) subunit gene family. The protein encoded by the α10 nAChR subunit gene is most similar ...
Búsqueda de sitios de unión a ligandos en receptores nicotínicos de acetilcolina humano de tipo α7 y α4(2)β2(3)
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)
Avaliação da expressão gênica e proteica dos receptores nicotínicos em modelo in vitro de infecção por SARS-CoV-2 com e sem superexpressão de ECA2
(Universidade Federal de São Paulo, 2023-02-27)
Introdução: O SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) é o vírus causador da COVID-19 (Coronavírus disease 2019), doença decretada pandêmica em 2020. A entrada do vírus na célula hospedeira ocorre após ...
Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms
(Elsevier, 2013-08)
This work presents the design and synthesis of a series of novel 2-benzylquinuclidine derivatives, comprising 12 methiodide and 11 hydrochloride salts, and their structural and pharmacological characterization at the human ...